ceesdekker.net Secrets
ceesdekker.net Secrets
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‘The second is nanopores, which can be our oldest line of analysis and which has now resulted in DNA sequencers depending on nanopores. We pull personal DNA strands through a nanopore and can then study off the nucleotide sequence. Very lately, we even managed to read out only one protein for The 1st time working with This method. But this line of analysis is not merely about creating tools, but also about serious Organic queries.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating common and irregular types with recombination purpose.
Dynamics of initiation, termination and reinitiation of DNA translocation because of the motor protein EcoR124I
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
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Our exploration ranges from the biophysics of DNA to synthetic cells and further than. Be sure to take a look down below for the spectrum of our latest initiatives.
‘Initially we checked out Organic systems using a Bodily perspective and acted on the basis in the applications we knew. It took a couple of years ahead of we begun Operating far more on the large Organic challenges. I then started to get in touch with it nanobiology, a expression that didn't exist at some time.
Nanopores characterize a sublime and functional Resource to evaluate solitary molecules. We investigation novel detection modes with reliable-condition nanopores and also a variety of strategies to measure proteins with nanopores. Tasks encompass the following:
2003, demonstrated the main biosensors built outside of a carbon nanotube; solved the construction and mechanism of DNA repair proteins; and discovery of a completely new procedure for fabricating stable-condition nanopores for DNA translocation
1). The existing–voltage curves showed important modulations with gate voltage, even at room temperature, which was in keeping with band bending inside a ~0.six eV bandgap semiconducting nanotube. These data also confirmed which the conductance could possibly be modulated by six orders of magnitude by shifting the gate voltage. The results of this do the job — a space-temperature transistor constructed from just one carbon nanotube molecule — ended ceesdekker up published in Character in May well 1998.
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2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes